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Generate Highly Contiguous Assemblies by Incorporating Long-range Sequence Information into Your Next-generation Sequencing Data

Arima Hi-C is a proximity ligation sample preparation method that detects spatially proximal DNA interactions within cells. This approach lets you leverage the 3D dimensional chromosome folding structure and preserve long-range sequence information prior to sequencing with standard library prep and NGS workflows.

Mapping the architecture of the genome through DNA interactions uniquely captures biological properties of chromosomes within cells, providing novel insights into the structure and function of the genome.

Why Choose Arima Hi-C for Genome Assembly?

Proven performance for generating the most accurate and contiguous chromosome-spanning assemblies

Fast and user-friendly workflows to go from sample to discovery in as little as 6 hours

Quality you can trust, with built-in QC steps to ensure you get reliable sequencing results every time

Generate multiple data types, including long-range sequence and genome structural information, from a single assay

No need for high molecular weight (HMW) DNA extraction, so you can use any sample type with little DNA input required

Fully Phased Genome Assemblies

Phased genome assemblies, or haplotype-resolved genomes, provide a more comprehensive picture of the genome and its complex genetic variations. Understanding the long-range linkages enhances your ability to advance precision medicine.

Arima-Lab-Genome-Assembly

Comparative analysis of Anna’s hummingbird genome assemblies to optimize sequencing and assembly strategy for high-quality reference genomes.

Scaffolding & Error Correction of Assemblies

Arima Hi-C technology is an essential tool for correcting assembly errors, scaffolding of contigs, and providing chromosome-spanning
contiguity to any assembly.

A Trusted Partner to Global Consortia

Arima Genomics is a proud partner of the Vertebrate Genome Project (VGP) Phase 1 initiative to generate reference-quality assemblies of 260 species. Coupled with PacBio long-read sequencing, Arima Hi-C was selected for generating long-range scaffolds, gap filling, and error correction.

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Arima Genomics is a technology partner of the VGP Phase 1.

Michael Quail

Principal Scientific Manager of DNA Pipelines, Wellcome Sanger Institute

 “The newer Arima kits are being used because we found them to be robust across a range of tissue types from diverse vertebrate and invertebrate species. Kit robustness to a diversity of samples is an essential requirement for the Darwin Tree of Life Project.” 

Explore Our Genome Assembly Resources

Learn more about some of the hundreds of genomes assembled using Arima-HiC.

High Coverage HiC

The Arima High Coverage HiC Kit lets you get more from your next-generation sequencing data for reference-quality phased genome assemblies.

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