The 2020 Keystone Symposia Cancer Epigenetics: New Mechanisms and Therapeutic Opportunities in conjunction with the joint conference, Gene Regulation: From Mechanisms to Disease, co-organized by Karen Adelman and Patrick Cramer, will highlight state-of-the art advances in methods, mechanistic insights, and drug discovery efforts across these interrelated fields. Furthermore, results from exome- and genome-wide sequencing efforts point toward major roles for chromatin regulatory machinery in cancer. These data emphasize the immediate need for