Benefits of the Promoter Capture HiC Workflow
The HiC+ Kit and Promoter Capture HiC workflow are designed to speed time to discovery of critical promoter interactions.
Characterize regulatory differences between samples
Generate conformational profiles of promoter regions
Identify novel biomarkers and therapeutic targets
Detect High-Quality Interactions
Arima Promoter Capture HiC lets you identify key linkages between promoters and their target genes with a high cis:trans ratios and high on-target read coverage at low sequencing depths.
Promoter Capture HiC captures differential regulation of SOX2 between IMR90 and MCF70 cells. 100M reads yielded 3kb resolution of promoter interactions with regulatory elements from as few as 80k cells.
Arima Custom Capture Workflow
With our easy-to-use workflow you can rapidly go from sample to discovery.
Rapid 6-hour Protocol
Begin with as little as 80k cells, compatible with most sample types
Library + Target Capture
Library Prep module + 1-hour Hybridization
Optimized for amplification performance, high % on target reads, and RNA-based capture of genome-wide promoter contacts
Illumina Next Generation Sequencing
100M reads recommended for <5kb resolution of promoter contacts
Open and Optimized Bioinformatics Pipelines
Built using the open-source HiCUP and CHiCAGO tools
Changhoon KimChanghoon Kim, PhD, Chief Technology Officer, Macrogen, Inc.
Explore Our Resources
Learn more about how you can use Arima-HiC+ for Promoter Capture in your research: