Banner Image

 

Gain Higher Resolution Across More Samples with Arima Capture-HiC+

 

The three-dimensional (3D) organization of chromatin can be determined through genome-wide next generation sequencing (NGS) after chromatin conformation capture (3C), a technique called Hi-C. High-resolution maps of chromatin interactions provide insight into chromatin organization and gene regulation in disease contexts. Deep sequencing and high levels of sequencing coverage are necessary to achieve the resolution necessary for chromatin studies. Achieving the level of depth and coverage required for the whole genome (whole genome sequencing) can take a lot of time, cost, and data processing power.

In these cases, Capture Hi-C can be a better alternative. Arima Capture-HiC+ combines the 3C technology of Hi-C with the targeted results of hybridization capture. This targeted next generation sequencing technique uses biotinylated probes to capture, or enrich, regions of interest, saving time and money. Targeting specific regions of the genome focuses results, lowering the barrier to generating high-resolution Hi-C data. 

Want access to Arima Capture-HiC+?

 

The Arima Capture-HiC+ platform panel enables researchers to:

  • Understand gene regulatory mechanisms by assigning distal regulatory elements to promoter regions across the genome
  • Identify novel therapeutic, diagnostic or prognostic markers by linking human disease-associated variants to their target genes
  • Generate conformational profiles of specified chromosome loci by targeted enrichment of defined regions 

Benefits and Features:

  • Sample-to-Library in 3 Days | Streamline your workflow by adding the Arima Library Prep and Arima Capture modules to optimized for the Arima-HiC+ platform
  • Flexible Design | Choose between our pre-designed Human or Mouse promoter panels, or design your own
  • Tunable Performance | Enhance resolution across targeted regions with high fold enrichment fewer reads*

*compared to genome-wide Hi-C
 


Fill out the form below to be the first to get access to Arima Capture-HiC+

 

 


  •  

Flexible Ordering Options for Promoter, Variant and Region Capture Hi-C

Arima's ordering options are flexible. Purchase as a bundle or separately

Bundle everything with the Arima Capture-HiC+ Kits, which include:

  • Arima HiC+ Kit
  • Arima Capture Module
  • Arima Library Prep Module

Separate Arima Capture Modules, which include:

  • 8 rxn Arima Human Promoter Panel
  • 8 rxn Arima Mouse Promoter Panel
  • 16 rxn Arima Custom Capture Panels (Tiers 1–5) 

Separate Library Prep Module, which includes:

  • 16 rxn Arima Library Prep kit 

Request a quote here, or sign up for early access using the form above.



Promoter Capture 

Variant Capture
 
Region Capture 
 
 

 

 

Uncover Chromatin Conformation and Epigenomic Features
Around Targeted Genes

The Arima-HiC+ kit is a highly simplified and robust protocol that streamlines Hi-C to a 6-hour workflow followed by library prep and next-generation sequencing. The Arima-HiC+ kit empowers researchers to leverage Hi-C technology to perform either genome-wide or targeted identification of promoter-enhancer interactions, link non-coding, disease-associated variants to target promoters, and uncover how perturbations in genome conformation impact gene regulation in disease contexts

  • Proven performance—greater accuracy of chromatin loop and topological domain detection even at reduced sequencing depths
  • Fast and user-friendly workflow—rapid 6-hour, Hi-C workflow
  • Assured quality—rapid and easy library QC steps that accurately predict library quality, ensuring sequencing success
  • Flexible input requirements—Support for a broad range of sample types and an optimized protocol for low sample input