About the Webinar
In this webinar, we explore a groundbreaking case of a rare large B-cell lymphoma (LBL) with an IRF4 rearrangement detected using Arima’s 3D genomics technology. Traditional diagnostic methods, including FISH and RNA-seq, failed to detect the critical IRF4 rearrangement in this case.
Learn why a 3D genomics approach, an NGS method that preserves 3D genome structure, can detect diagnostic and therapeutically informative gene rearrangements that traditional methods miss.
Key Takeaways
- Going beyond FISH and RNA: Learn how Hi-C sequencing can reveal hidden genomic rearrangements that are crucial for accurate diagnosis and therapy selection, offering a clearer path to effective treatment for patients.
- Looking genome-wide: Consider the implications of looking at the broader landscape of genomic abnormalities that a genome-wide approach like Hi-C provides.
Meet the Speakers
Mina Xu, MD
Yale School of MedicineDr. Mina L Xu, MD, is the Director of Hematopathology and Professor of Pathology and Laboratory Medicine at Yale School of Medicine, specializing in diagnosing blood diseases and cancers. She is an internationally recognized academic pathologist and has recently been appointed as the Founding Director of Yale Pathology's Expert Consultation Practice. Dr. Xu's research focuses on the pathogenesis of hematopoietic malignancies, aiming to translate findings into diagnostic and therapeutic advancements in the field. Specifically, she is working on spatial multi-omics of lymphomas in transformation and in the development of novel cancer biomarkers.
Anthony Schmitt, PhD
Arima GenomicsAnthony Schmitt, PhD, is the SVP of Science at Arima Genomics, where his expertise in 3D genomics has been pivotal to the company's development of Hi-C technology and its applications in genomics research. He received his PhD from the University of California, San Diego, where he developed novel methodologies for understanding gene regulation using 3D genomics approaches. Since Arima’s inception, Anthony has led the development of the core Arima Hi-C chemistry and technology platform, as well as industry partnerships and academic collaborations.