November 15, 2021
Understanding Cancer — Understanding Chromatin Architecture
Cancer often exhibits multiple genetic, epigenetic, and chromosomal alterations. To elucidate the underlying complexities, oncology research focused on noncoding regions of the genome has revealed many new mechanisms affecting oncogene expression. Here, Dr. Elisa Oricchio shares her work to better understand cancer through 3D chromatin architecture.
In this webinar, you will hear Dr. Elisa Oricchio discuss her recent findings and learn how:
- Chromosomal alterations including enhancer hijacking and epigenetic changes lead to modifications of the chromatin architecture in lymphoma
- Epigenetic markers modulate chromatin interactions between regulatory elements to support transcriptional oncogenic programs
- Chromosomal translocation and epigenetic changes can induce allele-specific chromatin configurations supporting monoallelic oncogene expression