About the Webinar
Nodal T-follicular helper cell lymphoma (nTFHL) is a prevalent subtype of T-cell lymphoma with a dismal 5-year overall survival rate of 30-40%. While previous studies have highlighted recurrent alterations in epigenetic modifier genes, the direct impact of 3D chromatin architecture on the gene expression changes driving T-cell lymphomagenesis remains poorly understood.
In this webinar, you’ll learn how Hi-C sequencing uncovers nTFHL-specific alterations in chromatin organization and enhancer-promoter interactions, offering novel insights into the molecular underpinnings of nTFHL.
Key Takeaways
- Distinct chromatin conformations create a lymphoma-specific gene regulatory landscape in TFHL.
- The role of promoter-super enhancer/enhancer loops in driving aberrant gene regulation in nTFHL.
Meet the Speakers
Makoto Iwasaki, MD, PhD
Massachusetts General Hospital Cancer CenterMakoto is a hematologist and post-doctoral research fellow in Dr. Salvia Jain’s Laboratory at the Massachusetts General Hospital Cancer Center. He received his MD and PhD from Kyoto University, Japan. Makoto's research focuses on advancing translational research in hematological malignancies through data-driven approaches including multi-omic analysis and machine learning to unravel gene regulatory mechanisms and their clinical implications. Currently, he is investigating the role of 3D chromatin organization in the development of T-cell lymphoma, with the ultimate goal of identifying novel therapeutic targets.
Allyson Whittaker, PhD
Arima GenomicsAllyson is the Technical Applications Manager at Arima. She earned her PhD from MIT, where she studied DNA replication and cell cycle regulation under the mentorship of Dr. Terry Orr-Weaver at the Whitehead Institute. She completed a postdoctoral fellowship in neuroscience with Dr. Paul Sternberg at Caltech. Following her transition into the biotech industry, Allyson spent eight years in drug discovery. In 2020, she brought her extensive background and expertise to Arima Genomics, where she leads the technical support team.