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About the Webinar:

Glioblastoma multiforme (GBM) encompasses brain malignancies marked by phenotypic and transcriptional heterogeneity thought to render these tumors aggressive, resistant to therapy, and inevitably recurrent. However, little is known about how the spatial organization of GBM genomes underlies this heterogeneity and its effects.

Dr. Argyris Papantonis, Professor for Translational Epigenetics at the University of Goettingen in Germany, illuminates our understanding of the spatial organization of glioblastoma genomes, elucidating its impact on tumor heterogeneity and providing valuable insights for targeted therapies.

Key Takeaways:

  • Groundbreaking work from analyzing high-resolution Hi-C data, that unveils over 3,100 SV’s and more than 6,300 neoloops that emerge from these SVs, providing valuable insights into the complex genomic landscape
  • How the pervasive, uneven, and idiosyncratic occurrence of neoloops sustain tumor-specific transcriptional programs via the formation of new enhancer-promoter contacts, by combining Hi-C data with chromatin folding simulations
  • How patient-specific vulnerabilities and biomarkers are uncovered by even moderately recurrent neoloops

Meet the Speakers:

Kristin Sikkink, PhD

Director of Research, Arima Genomics

Kristin is our newly appointed Director of Research and holds a PhD in Biology. She leads and manages Arima's clinical and discovery research programs.

Argyris Papantonis, PhD

Professor for Translational Epigenetics, University of Goettingen in Germany

Argyris studied biology at the University of Athens, where he also obtained his Ph.D. Following postdoctoral work with Peter R. Cook at the University of Oxford, he set up his lab at the Center for Molecular Medicine Cologne, Germany. Since 2018 he is a Professor for Translational Epigenetics at the Medical Faculty of the University of Goettingen, Germany.