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About the Webinar

Kaposi sarcoma-associated herpesvirus (KSHV) is a human herpesviruses that is known to cause several diseases, including Kaposi sarcoma, primary effusion lymphoma, and AIDS-related multicentric Castleman disease. KSHV establishes a latent infection in the cell nucleus, but where KSHV episomal genomes are tethered and the mechanisms underlying KSHV lytic reactivation are unclear.

During this webinar, Dr. Yoshihiro Izumiya shares how his lab used Capture Hi-C to identify KSHV episome tethering sites on host chromosomes and characterize the surrounding nuclear microenvironment of KSHV episomes.

Key Takeaways

  • Infected mini-herpesviral chromatin is organized similarly to host cell chromatin and is regulated by cellular proteins.
  • 3D genome technologies identify where viral chromatin tethers on host chromosomes and reveal CHD4 as a key histone enzyme that facilitates KSHV to establish latency and inhibits reactivation in the absence of stimuli.
  • Hi-C technology provides insights into 3D viral chromatin structure and reveals structural changes induced during reactivation.

Meet the Speakers

Yoshihiro Izumiya, DVM, PhD

Professor, Department of Dermatology, UC Davis School of Medicine

Dr. Yoshi Izumiya is a molecular virologist at UC Davis and focuses on molecular mechanisms of Kaposi's sarcoma-associated herpesvirus reactivation from latently-infected cells. Dr. Izumiya utilizes viral mini-chromatin and viral-host interaction and entry to understand cellular protein functions.

Kristin Sikkink, PhD

Scientist, Arima Genomics

Dr. Kristin Sikkink is a Senior Scientist in Scientific Affairs and holds a PhD in Biology. At Arima, she spearheads research and development initiatives.