About the Webinar
This webinar explores the role of extrachromosomal DNA (ecDNA) in cancer biology, with a focus on Small Cell Lung Cancer (SCLC). Dr. Sihan Wu presents on his findings from a novel preclinical system using patient-derived xenograft models.
Attendees will learn how cutting-edge 3D genomic technologies reveal crucial interactions between MYC and distant loci, and gain insights into ecDNA segregation mechanisms. The webinar demonstrates how combining traditional cytogenetics with modern sequencing techniques advances our understanding of ecDNA biology in cancer.
Key Takeaways
- The re-discovery of ecDNA: Revisiting ecDNA biology by combining old-school cytogenetics with modern sequencing technology.
- Clinical implications of ecDNA: Address how ecDNA promotes malignant transformation, tumor evolution, and therapy resistance.
- The application of 3D genomic technologies in ecDNA research: Showcase examples of 3D genomic sequencing methods, such as HiC, in studying ecDNA structure and function.
Meet the Speakers
Sihan Wu, PhD
University of Texas Southwestern Medical CenterDr. Sihan Wu is an Assistant Professor of Children’s Medical Center Research Institute at UT Southwestern, where his lab investigates the functional roles and maintenance mechanisms of extrachromosomal DNA (ecDNA) in cancer. His research integrates expertise in cancer genetics and genomics to unravel how ecDNA drives tumor evolution and therapy resistance and develop ecDNA-specific targeting strategies.
Andrew Kao
Arima GenomicsAndrew is a Technical Applications Scientist with a deep understanding of Arima HiC technology and a dedicated focus on supporting customers in advancing their research. Andrew leverages his expertise to provide technical guidance, troubleshoot experimental workflows, and ensure the successful implementation of Arima HiC technologies for researchers and industry partners. He attended the University of California, Riverside.