About the Webinar
This webinar explores how cutting-edge genomic technologies are reshaping our understanding of Alzheimer’s disease risk by focusing on the 3D genome and epigenomic changes in human microglia across the lifespan. Attendees will gain insights into how age-related shifts in microglial gene regulation contribute to neuroinflammation and Alzheimer’s disease pathogenesis.
What You Will Learn:
- Discover how 3D genome mapping and epigenomic profiling reveal dynamic changes in microglial gene regulation with aging, highlighting new mechanisms underlying Alzheimer’s disease risk
- Learn about the stepwise increase in Alzheimer’s genetic risk associated with age, and how specific gene networks (including MS4A6A, TRIM14, EGOT, and SLAMF) drive the transition from developmental to inflammatory microglial functions in older adults
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Meet the Speakers
Reuben Yaa
UK Dementia Research InstituteReuben Yaa is a research associate with UK Dementia Research Institute, based at the Imperial College London Centre. He leads projects on investigating how the epigenome of brain cell types over a lifespan modulate the consequences of genetic variations associated with neurodegenerative diseases, aiming to uncover temporal epigenomic predisposition to disease pathology.
Allyson Whittaker
Arima GenomicsAllyson Whittaker is the Technical Applications Manager at Arima. She earned her PhD from MIT, where she studied DNA replication and cell cycle regulation under the mentorship of Dr. Terry Orr-Weaver at the Whitehead Institute. She completed a postdoctoral fellowship in neuroscience with Dr. Paul Sternberg at Caltech. Following her transition into the biotech industry, Allyson spent eight years in drug discovery. In 2020, she brought her extensive background and expertise to Arima Genomics, where she leads the technical support team.