About the Webinar
This webinar introduces Capture-C MPRA, a groundbreaking genomic technology that integrates 3D genome mapping with high-throughput functional assays to unravel the complex regulatory landscape of gene expression. Attendees will discover how this dual-purpose method links physical DNA interactions with regulatory activity, enabling precise mapping of enhancers and silencers to their target genes in a single experiment.
Key Takeaways:
- Discover how Capture-C MPRA combines promoter capture Hi-C and massively parallel reporter assays to simultaneously map promoter interactions and measure the regulatory activity of distal elements.
- Learn how this approach systematically identifies and assigns enhancers and silencers to specific genes, revealing new insights into enhancer-promoter specificity and the rules governing gene regulation.
Meet the Speakers
Coline Arnould, PhD
UCSFColine Arnould is a molecular biologist with expertise in DNA damage repair, chromatin architecture, and gene regulation. During her Ph.D. with Dr. Gaëlle Legube in France, Coline uncovered a critical role for 3D genome organization in double-strand break repair and cancer. As a postdoctoral researcher in Dr. Nadav Ahituv’s lab at UCSF, she now leverages cutting-edge genomic tools to investigate gene regulatory elements within the context of chromatin architecture.
Allyson Whittaker
Arima GenomicsAllyson Whittaker is the Technical Applications Manager at Arima. She earned her PhD from MIT, where she studied DNA replication and cell cycle regulation under the mentorship of Dr. Terry Orr-Weaver at the Whitehead Institute. She completed a postdoctoral fellowship in neuroscience with Dr. Paul Sternberg at Caltech. Following her transition into the biotech industry, Allyson spent eight years in drug discovery. In 2020, she brought her extensive background and expertise to Arima Genomics, where she leads the technical support team.