About the Webinar
This webinar will introduce ec3D, a pioneering computational method that harnesses Hi-C data to map the 3D structure of extrachromosomal DNA (ecDNA) in cancer, revealing how these circular DNA elements remodel genome architecture, activate oncogenes, and expose new therapeutic vulnerabilities unseen by traditional genomics.
Key Takeaways
- Discover how the 3D organization of ecDNA rewires chromatin domains to enable enhancer hijacking, oncogene activation, and adaptive tumor evolution.
- Learn how ec3D reconstructs spatial ecDNA conformations from Hi-C data to uncover long-range genomic interactions linked to gene dysregulation and therapy resistance.
- Explore how this new 3D mapping framework could pave the way for precision therapies targeting the spatial organization of cancer genomes.
Meet the Speakers
Vineet Bafna
University of California, San DiegoVineet Bafna, Ph.D., is a Professor of Computer Science and Engineering and the HDSI Chancellor’s Endowed Chair III at UC San Diego, known for pioneering research in cancer and population genomics. His work spans the discovery of complex cancer rearrangements and extrachromosomal DNA, co-founding Abterra Inc. and Boundless Bio, and authoring over 200 influential papers in top journals.
Damien Porter
Arima GenomicsDamien Porter is the Western North America Strategic Account Executive for Arima Genomics. He comes to us with 20+ years experience working for companies we all know from Bio-Rad, Qiagen and Affymetrix to Olink before joining Arima in 2024. Damien attended UC Santa Barbara and earned his Bachelor's Degree in Physiology and Cell Biology and his B.A.Sc. in Biochemistry and Molecular Biology.