About the Webinar
Discover how 3D chromatin organization acts as a master regulator of leukemia biology, learn cutting-edge approaches to profile spatial genome architecture in cancer, and understand how linking chromatin structure to gene expression networks can identify new precision medicine strategies for improving patient outcomes.
Key Takeaways
- Learn how 3D chromatin conformation capture can distinguish leukemia subtypes and pinpoint their cells of origin by mapping lineage-defining regulatory hubs.
- Explore how 3D genome profiling uncovers intra‑tumor heterogeneity in T‑ALL, providing new biomarkers to anticipate and monitor therapy response.
- See how chromatin interaction matrices expose structural variants and enhancer hijacking events that drive oncogene activation and leukemic transformation.
- Understand how integrating 3D genome architecture with transcriptional programs offers a powerful framework for precision diagnosis and targeted intervention in human leukemias.
Meet the Speakers
Francesco Boccalatte, PhD
Candiolo Cancer InstituteFrancesco is the Principal Investigator of the Genomic Architecture of Cancer lab at the Candiolo Cancer Institute in Turin, Italy. His lab researches the epigenetic mechanisms that drive tumor formation, maintenance and resistance to therapy, especially in the context of acute leukemias. By integrating multi-modal characterization of transcriptome, epigenome and chromatin structure, his lab aims to find new actionable targets for personalized leukemia treatment.
Allyson Whittaker, PhD
Arima GenomicsAllyson is the Technical Applications Manager at Arima. She earned her PhD from MIT, where she studied DNA replication and cell cycle regulation under the mentorship of Dr. Terry Orr-Weaver at the Whitehead Institute. She completed a postdoctoral fellowship in neuroscience with Dr. Paul Sternberg at Caltech. Following her transition into the biotech industry, Allyson spent eight years in drug discovery. In 2020, she brought her extensive background and expertise to Arima Genomics, where she leads the technical support team.