About the Webinar
In this webinar, we will explore the dynamic epigenetic landscape of the adult mouse brain, highlighting how changes in DNA methylation and 3D genome conformation shape gene regulation from youth to old age. Attendees will gain insights into the mechanisms driving aging-related neural diversity and discover emerging computational approaches for predicting gene expression changes linked to neurodegeneration.
What You Will Learn:
- Uncover how chromatin conformation and DNA methylation diversity establish distinct regulatory networks across brain cell types, illuminating molecular underpinnings of neural complexity.
- Learn about age-associated epigenetic shifts, including transposable element demethylation and strengthened TAD boundaries at CTCF sites, and their implications for neural aging and disease risk.
- Discover new deep-learning models that integrate multi-modal epigenetic features to predict age-related changes in gene expression, with potential applications for brain health and disease research.
Save Your Spot
Meet the Speakers
Qiurui Rachel Zeng
UCSD & Salk Institute, Ecker LabRachel is a fifth-year graduate student at the Joe Ecker Lab at UC San Diego and Salk Institute. Her interests in epigenome and aging started in college, where she worked on epigenetic reprogramming for retina rejuvenation. She then decided to devote her PhD time into understanding the methylation and 3D genome in the normal adult brain and then extending to the aging trajectory.
Andrew Kao
Arima GenomicsAndrew is a Technical Applications Scientist with a deep understanding of Arima HiC technology and a dedicated focus on supporting customers in advancing their research. Andrew leverages his expertise to provide technical guidance, troubleshoot experimental workflows, and ensure the successful implementation of Arima HiC technologies for researchers and industry partners. He attended the University of California, Riverside.