About the Webinar
Explore the applications of Hi-C sequencing in pediatric oncology. In this webinar, you’ll learn how Hi-C sequencing not only matches the accuracy of traditional diagnostic methods in detecting known genomic rearrangements in pediatric leukemia and sarcoma specimens, but also goes beyond to uncover previously undetected rearrangements. These newly identified rearrangements could significantly impact diagnosis, prognosis, and treatment decisions.
Additionally, discover how Hi-C reveals the underlying chromosomal mechanisms of these genomic rearrangements, including the detection of extra-chromosomal DNA (ecDNA).
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What Will You Learn?
- The uniqueness of Hi-C sequencing: Explore how Hi-C preserves the 3D conformation of the genome and why this is critical for detecting genomic rearrangements.
- Clinical concordance and novel genomic rearrangements: Discover how Hi-C not only achieved 100% concordance with traditional diagnostic tests in pediatric heme and solid tumor specimens, but also identified critical gene fusions not previously detected which could impact diagnosis, prognosis, and therapy selection.
- Broad compatibility with clinical samples: Understand why Hi-C excels with a range of challenging sample types, including FFPE tissues, making it a practical method for implementation into clinical NGS workflows.
Meet the Speakers
Midhat Farooqi, MD, PhD
Children’s Mercy Kansas CityMidhat Farooqi, MD, PhD is a molecular genetic pathologist and the Director of Molecular Oncology for the Department of Pathology & Laboratory Medicine at Children’s Mercy Kansas City, and also for the Genomic Medicine Center at the Children’s Mercy Research Institute. He completed his medical and graduate studies at the University of Texas Southwestern Medical Center and is currently an Associate Professor of Pathology at the University of Missouri-Kansas City School of Medicine. He is also a member of the University of Kansas Cancer Center. Dr. Farooqi specializes in genomic medicine and precision oncology, with a focus on advancing diagnostic and therapeutic approaches for pediatric cancer through cutting-edge genomic techniques.
Anthony Schmitt, PhD
Arima GenomicsAnthony Schmitt, PhD, is the SVP of Science at Arima Genomics, where his expertise in 3D genomics has been pivotal to the company's development of Hi-C technology and its applications in genomics research. He received his PhD from the University of California, San Diego, where he developed novel methodologies for understanding gene regulation using 3D genomics approaches. Since Arima’s inception, Anthony has led the development of the core Arima Hi-C chemistry and technology platform, as well as industry partnerships and academic collaborations.