Explore Arima Hi-C Technology
Arima Hi-C is a proximity ligation method that captures the organizational structure of chromatin in three dimensions, where genomic sequences that are distal to each other in linear distance can be closer to each other in the 3D space.
The high-resolution, genome-wide map of interacting genetic loci that is generated from Hi-C data can then be used across multiple genomic applications, including identification of promoter-enhancer interactions for gene regulation studies, detection of structural rearrangements, and scaffolding contigs for genome assemblies to define chromosomes de novo.
Using a 3D genomics approach with Arima Hi-C provides information on both the sequence + structure of the genome.
Learn How Arima Hi-C Technology Works
Our advanced Hi-C technology enables a range of products and applications by providing unparalleled access to the sequence and structure of any genome.
The core of our technology is proximity ligation — whereby nuclear DNA is crosslinked, digested with restriction enzymes, biotin-labeled, and proximity-ligated before sequencing using standard NGS approaches. This lets you capture critical 3D genome organization and long-range genetic information in one assay.
Hi-C Prep
Rapid 6-hour Protocol
Compatible across a wide range of sample types including fresh/frozen tissue, cell lines, and FFPE samples
Library Prep
Pre-validated Library Prep Protocol
Use our standard or low DNA input library prep protocols
Sequencing
Illumina Next Generation Sequencing
Get more from your next generation sequencing data
Data Analysis
Powerful Analysis Tools
Use our open-source tools and pipelines to align and visualize your data
Discover How Arima Hi-C Technology Can Benefit Your Science
Epigenetics
Understand how spatial relationships in genome structure impact gene regulation, cellular development, and disease processes.
Human Health
Accelerate the path to novel biomarkers and therapies with 3D genomic insights into disease mechanisms to improve human health.
Genome Assembly
Construct reference-quality, chromosome-spanning assemblies and phase haplotypes to explore genome function and species evolution.
Webinar: Hear More About the Benefits of Arima Hi-C for Your Research
Discover Our Products
Genome-Wide HiC
Explore genome-wide chromatin conformation
HiChIP
Discover dynamic gene regulatory mechanisms
Capture HiC
Capture targeted regions of the genome with high resolution
Promoter Capture HiC
Use our well-established panels to explore gene regulation in humans and mice
High Coverage HiC
Get more from your next generation sequencing data
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