Large B-cell lymphoma with mystery rearrangement: Applying Hi-C to the detection of clinically relevant structural abnormalities

Publication
Written By Erin Davis

Reference:

Prior, et al.

Br J Haematol. 205(3):1225-1229.

Full text:

https://onlinelibrary.wiley.com/doi/10.1111/bjh.19611

Abstract:

Large B-cell lymphoma with IRF4-rearrangement (LBL-IRF4R) is a rare non-Hodgkin lymphoma (NHL) subtaype that was identified in 2011, and was first included as a unique disease entitty in the 2017 World Health Organization classification of haematopoietic and lymphoid neoplasms. While LBL-IRF4R should demonstrate the rearrangement of IRF4, we present a case in whcih rearrangment was not revealed by FISH testing, but was subsequently proven by novel Hi-C technology.

Erin Davis
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