Aventa FusionPlus based on Hi-C FFPE Sequencing Detects Fusions Genome-Wide with High Sensitivity in Solid Tumors
Reference:
Hastie, et al.
16th Annual Meeting of the Cancer Genomics Consortium - Houston, TX
Abstract:
Chromosomal structural variants (SVs) play a significant role in cancer development and diagnostics. Although several techniques—such as FISH and targeted sequencing panels—exist for detecting SVs, they often have limitations such as throughput or relying on RNA, which is prone to degradation in formalin-fixed paraffin-embedded (FFPE) tissues. In contrast, Hi-C is a DNA-based next-generation sequencing (NGS) method that preserves the three-dimensional structure of the genome, enabling the detection of long-range genetic interactions and a wide spectrum of SVs.