About the Webinar
In this webinar, Dr. Takuya Nakagawa reveals how extrachromosomal DNA containing both human and viral sequences forms self-contained regulatory circuits that hijack 3D genome architecture to drive oncogene activation in HPV-associated cancers.
What You Will Learn:
- How hybrid ecDNA forms de novo enhancer elements at viral–host DNA junctions — and why this creates a new class of oncogenic regulatory structure
- How viral and human sequences within ecDNA engage in long-range 3D chromatin interactions to build self-sustaining gene activation circuits
- Why ecDNA-dependent transcription represents a novel therapeutic vulnerability, and how disrupting these enhancers reduces oncogene expression
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Meet the Speakers
Takuya Nakagawa, PhD
Chiba UniversityTakuya is a head and neck surgeon-scientist at Chiba University, Japan. His research focuses on the epigenetic and three-dimensional genome mechanisms that drive tumor development and therapeutic resistance, particularly in HPV-associated cancers. By integrating multi-modal analyses of the transcriptome, epigenome, and chromatin architecture, his work aims to uncover ecDNA-driven regulatory programs and identify novel therapeutic vulnerabilities.
Blake Skrable
Arima GenomicsBlake currently is an Associate Scientist at Arima Genomics executing various Hi-C-related studies and performing 3D genomic reconstruction for various clinical cases. He received a Master's in Molecular biology from UCSD by studying RNA and ribonucleoprotein quality control pathways.