December 21, 2021
Unraveling Complex Structural Variants and ecDNA in Childhood Brain Tumors
Structural variants (SVs) as well as extrachromosomal circular DNA (ecDNA) are known drivers of aggressive tumor growth, promoting oncogenic fusion genes and high oncogene copy number.
The Chavez lab studies the effects of SVs on the gene regulatory landscape of tumor genomes, as well as the frequency and diversity of ecDNA in different types of pediatric brain tumors. The lab aims to identify oncogenic mechanisms and novel tumor-dependency genes and pathways that may provide new targets for improved therapeutic approaches.
During this webinar, you will learn how how:
- 3D tumor genomes reveal complex inter-chromosomal rearrangements
- Structural variants lead to the activation of tumor-dependency genes through the formation of neo-TADs and enhancer hijacking
- ecDNA frequently amplifies one or several known and putative oncogenes and modulates regulatory rewiring